Dallas won 40-0 on the road against the Giants in Week 1.

They’re the 10-point home chalk against the Giants. The NFL odds for Week 10 show the Dallas Cowboys as the biggest favorite. The table below lists the opening NFL Week 10 odds for all 14 games on the schedule. The Monday Night Football puts two old AFL foes on the field as the Denver Broncos visit the Buffalo Bills. They’re facing the Los Angeles Chargers in the Week 9 MNF game. It’s the second straight game against an AFC West opponent for the Jets. The Raiders just whipped the New York Giants at home in Week 9. Sunday Night Football features the New York Jets as 1.5-point chalk at the Las Vegas Raiders. Looking to end a three-game skid following a 5-0 start, the 49ers are in Jacksonville to face the AFC South-leading Jaguars. One of the more intriguing games in the NFL Week 10 odds features the San Francisco 49ers and the Jacksonville Jaguars.

A look at all the opening NFL Week 10 odds can be found below with early predictions.

The Cowboys are the biggest favorite, laying 10 points against the Giants.

The Bears host the Panthers on Thursday Night Football to open NFL Week 10.

Mandatory Credit: Vincent Carchietta-USA TODAY Sports East Rutherford, New Jersey, USA Dallas Cowboys wide receiver KaVontae Turpin (9) celebrates his rushing touchdown with teammates during the second half against the Dallas Cowboys at MetLife Stadium.

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